Google is friggin' brilliant. They just came up with Mail Goggles. If you enable it, it prevents you from sending ill-advised drunken e-mails on late weekend nights. After a certain time of day, you have to perform a sobriety test, answering several math questions correctly within a set time limit. If you can't do it, you'll have to wait to send your e-mail (or reconsider sending it) until the next morning.